The Harold A. Iddles Lecture Series

 

Robert M. Cornphoto of Robert Corn for aesthetic purposes

Departments of Chemistry and Biomedical Engineering
Chemistry Department 
University of California, Irvine
Irvine, California 92697

 

 

Single Nanoparticle Biosensing with Surface Plasmon Resonance Imaging

September 19, 2017, 11am Parsons N104

Multiplexed surface bioaffinity adsorption measurements of nucleic acids and proteins with surface plasmon resonance imaging (SPRI) has become a mainstay tool for analytical chemists and biological researchers throughout the world. In this talk, I will describe our recent advances in nanoparticle-enhanced SPRI biosensing for (i) enzymatic detection of DNA, RNA and protein biomarkers at extremely low (femtomolar) concentrations [1] and (ii)  the measurement of the uptake of peptides and proteins into single hydrogel nanoparticles for potential drug delivery applications.[2]

1. J. B. Fasoli and R. M. Corn,"Surface Enzyme Chemistries for Ultrasensitive Microarray Biosensing with SPR Imaging" Langmuir, 31 9527-9536 (2015).
2. A. M. Maley, G. J. Lu, M. G. Shapiro and R. M. Corn, "Characterizing Single Polymeric and Protein Nanoparticles with Surface Plasmon Resonance Imaging Measurements"
ACS Nano, 11 7447-7456 (2017).

 

Nanorings, Nanocones and Nanocubes: Designing Nanotextured Surfaces with Unique Properties

September 19, 2017, 3pm Kingsbury S145

The properties of any surface - metal, semiconductor, glass, plastic or even liquid - can be altered drastically when textured or decorated with tiny sub-microscopic structures. These “nanostructures” can be rings, discs, cubes or more complicated shapes -- where each one is about 200 times smaller than the width of a human hair. "Nanotextured" surfaces can be designed to exhibit unique optical, wetting and chemical properties. They exist in nature on the surfaces of lotus leaves, moth eyes and the wings of butterflies. In this talk we will tour this 2D nanoworld. In his labs at UC Irvine, Dr. Corn and his team design and fabricate a variety of nanowire, nanoring and nanocone surfaces that can be used make broadband anti-reflective coatings, diffracting films that split up the laser beams, and “biochip” sensors that can quickly screen for proteins and DNA. 

 

Robert M. Corn is a Professor in the Departments of Chemistry and Biomedical Engineering at the University of California, Irvine. Prof. Corn received a B. A. in Chemistry from the University of California, San Diego, and a Ph. D. from the University of California, Berkeley. After a postdoctoral scientist position at the IBM San Jose Research Laboratory, in 1985 he joined the faculty in the Department of Chemistry at the University of Wisconsin-Madison where he was a Professor for 19 years. In 2004, Prof. Corn moved to the Department of Chemistry at the UCI where his research centers on the creation of new interfacial chemistries, spectroscopies and biochemistries. With over 150 publications, 12 patents and various awards, Prof. Corn has dedicated his career to the development and application of surface-sensitive spectroscopies such as surface plasmon resonance imaging, optical second harmonic generation, and polarization-modulation FTIR spectroscopy for the characterization of solid-liquid and liquid-liquid interfaces. His research interests include the development of new optical methods for multiplexed biosensing, the on-chip templated biosynthesis of nucleic acid and protein microarrays, the study of bioaffinity uptake into single polymer nanoparticles, the fabrication of nanostructured interfaces with unique optical, physical and properties, the synthesis of magnetic nanomaterials for biosensing and high frequency inductor applications, and the use of nucleic acids for DNA computing and other non-biological applications.


The Harold A. Iddles Lecture Series was established as an annual event of the Chemistry Department upon Professor Iddles' retirement in 1961. Chemistry alumni and friends established this fund to support a lecture series which includes one technical presentation and a second presentation of broader interest for the general public. This alumni gesture has served as a continuing recognition of Professor Iddles' service to the department as its head from 1929 to 1961, and of the educational and research programs he fostered.  Dr. Iddles, educated at Michigan State College (B.S., 1918) and State University of Iowa (M.S., 1922), received the Ph.D. in Chemistry from Columbia University in 1925 and then studied in Austria, Germany and England. During his long tenure at New Hampshire, he was widely recognized as an outstanding teacher and tireless advisor to students. For over thirty years some of the most distinguished chemists in the world have visited the University of New Hampshire as Iddles Lecturers. 

Past Iddles Lecturers

Erin E. Carlson Dietmar Seyferth David Parker
Arthur C. Cope Clayton H. Heathcock F. Sherwood Rowland
Louis F. Feiser Paul C. Lauterbur Peter Wipf
Frederick E. Brinckman Allen J. Bard R. Mark Wightman
James P. Collman Mark S. Wrighton Thomas V. O'Halloran
William N. Lipscomb, Jr. Anders Kjaer John LaMattina
Kenneth B. Wiberg Rudolph A. Marcus Pamela Bjorkman
George C. Pimentel Vincent du Vigneaud Mary J. Wirth 
Kurt Mislow Roand C.D. Breslow Barbara J. Finlayson-Pitts
R. Bruce Merrifield Daryle J. Busch Fred Wudl
Sidney H. Fox Manfred Eigen Raoul Kopelman
Francis O. Schmitt John D. Roberts Kim D. Janda 
Philip Aisen Gabor A. Somorjai Marsha I. Lester
Jerrold Meinwald Ira W. Levin William B. Tolman
George S. Hammond F. Albert Cotton Weihong Tan
Garry A. Rechnitz John T. Yates, Jr. Timothy M. Swager
Walter M. Stockmayer John E. McMurry Mark Ratner
R.M. Acheson Paul S. Anderson Peter Mahaffy
Louis P. Hammett Richard P. Wayne Cynthia Friend
Paul G. Gassman Chris Enke Isiah M. Warner
Orville L. Chapman Andrew D. Hamilton George M. Whitesides
Royce W. Murray Debbie C. Crans  
Michael J. Welch Jacqueline V. Barton  

 

Lectures are open to the public.  For more information, contact the Department of Chemistry at 603-862-1550.