Marc Boudreau

Phone: (603) 862-2556
Office: Chemistry, Parsons Hall Rm W223, Durham, NH 03824
Marc A. Boudreau

Research Interests

Our lab utilizes organic chemistry and chemical biology to study antibiotic resistance in bacteria. Organic synthesis is used to access new compounds that either exhibit unexplored mechanisms of inhibition against known bacterial targets, or that can function as probes for the identification of new targets. The synthesized compounds are evaluated in-house against clinically relevant bacterial strains and against their proposed enzyme targets. The mechanism of inhibition of active compounds is studied in detail, which is then utilized to inform the rational design of improved inhibitors.


  • Ph.D., University of Alberta
  • B.S., University of Victoria
  • B.S., Mount Allison University

Courses Taught

  • CHEM 546: Organic Chemistry Laboratory
  • CHEM 548: Organic Chemistry II
  • CHEM 651: Organic Chemistry I
  • CHEM 654: Organic Chemistry Laboratory
  • CHEM 755/855: Advanced Organic Chemistry
  • CHEM 777: Adv Syth and Char
  • CHEM 795/911: Top/Synthetic Organic Chem
  • INCO 790: Adv Rsrch Exp/Chemistry

Selected Publications

Lee, J., Boersma, A. J., Boudreau, M. A., Cheley, S., Daltrop, O., Li, J., . . . Bayley, H. (2016). Semisynthetic Nanoreactor for Reversible Single-Molecule Covalent Chemistry. ACS NANO, 10(9), 8843-8850. doi:10.1021/acsnano.6b04663

Leemans, E., Mahasenan, K. V., Kumarasiri, M., Spink, E., Ding, D., O'Daniel, P. I., . . . Mobashery, S. (2016). Three-dimensional QSAR analysis and design of new 1,2,4-oxadiazole antibacterials.. Bioorg Med Chem Lett, 26(3), 1011-1015. doi:10.1016/j.bmcl.2015.12.041

Ding, D., Boudreau, M. A., Leemans, E., Spink, E., Yamaguchi, T., Testero, S. A., . . . Mobashery, S. (2015). Exploration of the structure-activity relationship of 1,2,4-oxadiazole antibiotics.. Bioorg Med Chem Lett, 25(21), 4854-4857. doi:10.1016/j.bmcl.2015.06.044

Boudreau, M. A., Fishovitz, J., Llarrull, L. I., Xiao, Q., & Mobashery, S. (2015). Phosphorylation of BlaR1 in Manifestation of Antibiotic Resistance in Methicillin-Resistant Staphylococcus aureus and Its Abrogation by Small Molecules.. ACS Infect Dis, 1(10), 454-459. doi:10.1021/acsinfecdis.5b00086

Spink, E., Ding, D., Peng, Z., Boudreau, M. A., Leemans, E., Lastochkin, E., . . . Mobashery, S. (2015). Structure-activity relationship for the oxadiazole class of antibiotics.. J Med Chem, 58(3), 1380-1389. doi:10.1021/jm501661f

O'Daniel, P. I., Peng, Z., Pi, H., Testero, S. A., Ding, D., Spink, E., . . . Chang, M. (2014). Discovery of a new class of non-β-lactam inhibitors of penicillin-binding proteins with Gram-positive antibacterial activity.. J Am Chem Soc, 136(9), 3664-3672. doi:10.1021/ja500053x

Boudreau, M. A., Fisher, J. F., & Mobashery, S. (2012). Messenger functions of the bacterial cell wall-derived muropeptides.. Biochemistry, 51(14), 2974-2990. doi:10.1021/bi300174x

Liu, H., Boudreau, M. A., Zheng, J., Whittal, R. M., Austin, P., Roskelley, C. D., . . . Vederas, J. C. (2010). Chemical synthesis and biological activity of the neopetrosiamides and their analogues: revision of disulfide bond connectivity.. J Am Chem Soc, 132(5), 1486-1487. doi:10.1021/ja9102925

Wolfe, A. P., Tappert, R., Muehlenbachs, K., Boudreau, M., McKellar, R. C., Basinger, J. F., & Garrett, A. (2009). A new proposal concerning the botanical origin of Baltic amber.. Proc Biol Sci, 276(1672), 3403-3412. doi:10.1098/rspb.2009.0806

Spantulescu, M. D., Boudreau, M. A., & Vederas, J. C. (2009). Retention of configuration in photolytic decarboxylation of peresters to form chiral acetals and ethers.. Org Lett, 11(3), 645-648. doi:10.1021/ol802745n

Most Cited Publications