Marc Boudreau

ASSISTANT PROFESSOR
Office: Chemistry, Parsons Hall Rm W223, Durham, NH 03824
Marc A. Boudreau

Research Interests

Our lab utilizes organic chemistry and chemical biology to study antibiotic resistance in bacteria. Organic synthesis is used to access new compounds that either exhibit unexplored mechanisms of inhibition against known bacterial targets, or that can function as probes for the identification of new targets. The synthesized compounds are evaluated in-house against clinically relevant bacterial strains and against their proposed enzyme targets. The mechanism of inhibition of active compounds is studied in detail, which is then utilized to inform the rational design of improved inhibitors.

Education

  • Ph.D., University of Alberta
  • B.S., Mount Allison University
  • B.S., University of Victoria

Courses Taught

  • CHEM 545: Organic Chemistry
  • CHEM 696: Independent Study
  • CHEM 699: Thesis
  • CHEM 708: Spectroscopic Inv Organc Molec
  • CHEM 911: Synthetic Organic Chemistry I
  • CHEM 997: Sem/Organic-Inorganic
  • INCO 590: Rsrch Exp/Chemistry
  • INCO 790: Adv Rsrch Exp/Chemistry

Selected Publications

Lee, J., Boersma, A. J., Boudreau, M. A., Cheley, S., Daltrop, O., Li, J., . . . Bayley, H. (2016). Semisynthetic Nanoreactor for Reversible Single-Molecule Covalent Chemistry. ACS Nano, 10(9), 8843-8850. doi:10.1021/acsnano.6b04663

Leemans, E., Mahasenan, K. V., Kumarasiri, M., Spink, E., Ding, D., O’Daniel, P. I., . . . Mobashery, S. (2016). Three-dimensional QSAR analysis and design of new 1,2,4-oxadiazole antibacterials. Bioorganic & Medicinal Chemistry Letters, 26(3), 1011-1015. doi:10.1016/j.bmcl.2015.12.041

Ding, D., Boudreau, M. A., Leemans, E., Spink, E., Yamaguchi, T., Testero, S. A., . . . Mobashery, S. (2015). Exploration of the structure–activity relationship of 1,2,4-oxadiazole antibiotics. Bioorganic & Medicinal Chemistry Letters, 25(21), 4854-4857. doi:10.1016/j.bmcl.2015.06.044

Boudreau, M. A., Fishovitz, J., Llarrull, L. I., Xiao, Q., & Mobashery, S. (2015). Phosphorylation of BlaR1 in Manifestation of Antibiotic Resistance in Methicillin-Resistant Staphylococcus aureus and Its Abrogation by Small Molecules. ACS Infectious Diseases, 1(10), 454-459. doi:10.1021/acsinfecdis.5b00086

Spink, E., Ding, D., Peng, Z., Boudreau, M. A., Leemans, E., Lastochkin, E., . . . Mobashery, S. (2015). Structure–Activity Relationship for the Oxadiazole Class of Antibiotics. Journal of Medicinal Chemistry, 58(3), 1380-1389. doi:10.1021/jm501661f

O’Daniel, P. I., Peng, Z., Pi, H., Testero, S. A., Ding, D., Spink, E., . . . Chang, M. (2014). Discovery of a New Class of Non-β-lactam Inhibitors of Penicillin-Binding Proteins with Gram-Positive Antibacterial Activity. Journal of the American Chemical Society, 136(9), 3664-3672. doi:10.1021/ja500053x

Boudreau, M. A., Fisher, J. F., & Mobashery, S. (2012). Messenger Functions of the Bacterial Cell Wall-derived Muropeptides. Biochemistry, 51(14), 2974-2990. doi:10.1021/bi300174x

Liu, H., Boudreau, M. A., Zheng, J., Whittal, R. M., Austin, P., Roskelley, C. D., . . . Vederas, J. C. (2010). Chemical Synthesis and Biological Activity of the Neopetrosiamides and Their Analogues: Revision of Disulfide Bond Connectivity. Journal of the American Chemical Society, 132(5), 1486-1487. doi:10.1021/ja9102925

Wolfe, A. P., Tappert, R., Muehlenbachs, K., Boudreau, M., McKellar, R. C., Basinger, J. F., & Garrett, A. (2009). A new proposal concerning the botanical origin of Baltic amber. Proceedings of the Royal Society B: Biological Sciences, 276(1672), 3403-3412. doi:10.1098/rspb.2009.0806

Derksen, D. J., Boudreau, M. A., & Vederas, J. C. (2008). Hydrophobic Interactions as Substitutes for a Conserved Disulfide Linkage in the Type IIa Bacteriocins, Leucocin A and Pediocin PA-1. ChemBioChem, 9(12), 1898-1901. doi:10.1002/cbic.200800272

Most Cited Publications