Roy Planalp

My group studies Medicinal and Environmental Inorganic chemistry with a focus on iron, copper and zinc, both in essential and toxic senses of metal coordination and redox chemistry. We design metal ligands with conjugation to biomolecules and fluorophores in order to probe and modulate cellular metal metabolism of healthy and diseased states. Environmental analysis, sensing and nuclear medicine are also of interest. The Planalp group is currently accepting new graduate students.
Research Interests
- Medicinal Chemistry
- Inorganic Chemistry
- Synthetic Chemistry
Courses Taught
- CHEM 574: Chem Across Periodic Table
- CHEM 696: Independent Study
- CHEM 708/808: Spectroscopic Inv Organc Molec
- CHEM 774/874: Inorganic Chemistry
- CHEM 775: Inorganic Chemistry Laboratory
- CHEM 903: Adv Inorganic Chemistry I
- CHEM 904: Adv Inorganic Chemistry II
- CHEM 997: Seminar
- INCO 590: Student Research Experience
- INCO 790: Adv Rsrch Exp/Chemistry
Selected Publications
Fulton, L. A., Seitz, W. R., & Planalp, R. P. (2020). Aggregation of poly(N-isopropylacrylamide) homopolymer by Cu2+ and Zn2+: Significance for ratiometric metal ion indicators. POLYHEDRON, 191. doi:10.1016/j.poly.2020.114797
Wang, F., Planalp, R. P., & Seitz, W. R. (2019). A Cu(II) Indicator Platform Based on Cu(II) Induced Swelling that Changes the Extent of Fluorescein Self-Quenching. POLYMERS, 11(12). doi:10.3390/polym11121935
Fulton, L. A., Zhang, P., Seitz, W. R., Tsavalas, J. G., & Planalp, R. P. (2018). Dynamic Aggregation of Poly-N-Isopropylacrylamide Characterized Using Second-Order Scattering. APPLIED SPECTROSCOPY, 72(9), 1341-1348. doi:10.1177/0003702818778601
Abdalrahman, M. A., Abebe, F., Briggs, J., Kassel, W. S., Burdette, S. C., Seitz, W. R., & Planalp, R. P. (2017). A bifunctional 2,2 ':6 ',2 ''-terpyridine-based ligand for ratiometric Cu(II) sensing. JOURNAL OF COORDINATION CHEMISTRY, 70(7), 1123-1136. doi:10.1080/00958972.2017.1300660
Nyiranshuti, L., Kennedy, D. P., DiPasquale, A. G., Rheingold, A. L., & Planalp, R. P. (2016). TAMEisoquin, a novel tripodal fluorescent zinc sensor with high Zn(II) affinity and Zn(II)/Cd(II) selective fluorescence response: Synthesis, coordination geometry, spectroscopy, and comparative response to biometal ions. POLYHEDRON, 109, 147-153. doi:10.1016/j.poly.2016.01.024
Hatcher, H., Planalp, R., Cho, J., Tortia, F. M., & Torti, S. V. (2008). Curcumin: From ancient medicine to current clinical trials. CELLULAR AND MOLECULAR LIFE SCIENCES, 65(11), 1631-1652. doi:10.1007/s00018-008-7452-4
Jiao, Y., Wilkinson, J., Pletsch, E. C., Buss, J. L., Wang, W., Planalp, R., . . . Torti, S. V. (2006). Iron chelation in the biological activity of curcumin. FREE RADICAL BIOLOGY AND MEDICINE, 40(7), 1152-1160. doi:10.1016/j.freeradbiomed.2005.11.003
Abeysinghe, R. D., Greene, B. T., Haynes, R., Willingham, M. C., Turner, J. L., Planalp, R. P., . . . Torti, S. V. (2001). p53-independent apoptosis mediated by tachpyridine, an anti-cancer iron chelator. CARCINOGENESIS, 22(10), 1607-1614. doi:10.1093/carcin/22.10.1607
Torti, S. V., Torti, F. M., Whitman, S. P., Brechbiel, M. W., Park, G., & Planalp, R. P. (1998). Tumor cell cytotoxicity of a novel metal chelator. BLOOD, 92(4), 1384-1389. doi:10.1182/blood.V92.4.1384
PLANALP, R. P., ANDERSEN, R. A., & ZALKIN, A. (1983). DIALKYL BIS[BIS(TRIMETHYLSILYL)AMIDO] GROUP-4A METAL-COMPLEXES - PREPARATION OF BRIDGING CARBENE COMPLEXES BY GAMMA-ELIMINATION OF ALKANE - CRYSTAL-STRUCTURE OF [ZRCHSI(ME)2NSIME3[N(SIME3)2])2. ORGANOMETALLICS, 2(1), 16-20. doi:10.1021/om00073a005
Most Cited Publications