Roy Planalp

ASSOCIATE PROFESSOR
Phone: (603) 862-2471
Office: Chemistry, Parsons Hall Rm W233, Durham, NH 03824
Pronouns: He/him/his
Prof. Roy Planalp

My group studies Medicinal and Environmental Inorganic chemistry with a focus on iron, copper and zinc, both in essential and toxic senses of metal coordination and redox chemistry. We design metal ligands with conjugation to biomolecules and fluorophores in order to probe and modulate cellular metal metabolism of healthy and diseased states. Environmental analysis, sensing and nuclear medicine are also of interest. The Planalp group is currently accepting new graduate students.

Education

  • Ph.D., Inorganic Chemistry, University of California - Berkeley
  • B.S., Chemistry, Massachusetts Institute of Technology

Research Interests

  • Medicinal Chemistry
  • Inorganic Chemistry
  • Synthetic Chemistry

Courses Taught

  • CHEM 574: Chem Across Periodic Table
  • CHEM 576: Experimental Inorganic Chem
  • CHEM 696: Independent Study
  • CHEM 708/808: Spectroscopic Inv Organc Molec
  • CHEM 774/874: Inorganic Chemistry
  • CHEM 775: Inorganic Chemistry Laboratory
  • CHEM 903: Adv Inorganic Chemistry I
  • CHEM 904: Adv Inorganic Chemistry II
  • CHEM 997: Seminar
  • INCO 590: Student Research Experience
  • INCO 790: Adv Rsrch Exp/Chemistry

Selected Publications

Fulton, L. A., Seitz, W. R., & Planalp, R. P. (2020). Aggregation of poly(N-isopropylacrylamide) homopolymer by Cu2+ and Zn2+: Significance for ratiometric metal ion indicators. POLYHEDRON, 191. doi:10.1016/j.poly.2020.114797

Wang, F., Planalp, R. P., & Seitz, W. R. (2019). A Cu(II) Indicator Platform Based on Cu(II) Induced Swelling that Changes the Extent of Fluorescein Self-Quenching. POLYMERS, 11(12). doi:10.3390/polym11121935

Fulton, L. A., Zhang, P., Seitz, W. R., Tsavalas, J. G., & Planalp, R. P. (2018). Dynamic Aggregation of Poly-N-Isopropylacrylamide Characterized Using Second-Order Scattering. APPLIED SPECTROSCOPY, 72(9), 1341-1348. doi:10.1177/0003702818778601

Abdalrahman, M. A., Abebe, F., Briggs, J., Kassel, W. S., Burdette, S. C., Seitz, W. R., & Planalp, R. P. (2017). A bifunctional 2,2 ':6 ',2 ''-terpyridine-based ligand for ratiometric Cu(II) sensing. JOURNAL OF COORDINATION CHEMISTRY, 70(7), 1123-1136. doi:10.1080/00958972.2017.1300660

Nyiranshuti, L., Kennedy, D. P., DiPasquale, A. G., Rheingold, A. L., & Planalp, R. P. (2016). TAMEisoquin, a novel tripodal fluorescent zinc sensor with high Zn(II) affinity and Zn(II)/Cd(II) selective fluorescence response: Synthesis, coordination geometry, spectroscopy, and comparative response to biometal ions. POLYHEDRON, 109, 147-153. doi:10.1016/j.poly.2016.01.024

Hatcher, H., Planalp, R., Cho, J., Tortia, F. M., & Torti, S. V. (2008). Curcumin: From ancient medicine to current clinical trials. CELLULAR AND MOLECULAR LIFE SCIENCES, 65(11), 1631-1652. doi:10.1007/s00018-008-7452-4

Jiao, Y., Wilkinson, J., Pletsch, E. C., Buss, J. L., Wang, W., Planalp, R., . . . Torti, S. V. (2006). Iron chelation in the biological activity of curcumin. FREE RADICAL BIOLOGY AND MEDICINE, 40(7), 1152-1160. doi:10.1016/j.freeradbiomed.2005.11.003

Abeysinghe, R. D., Greene, B. T., Haynes, R., Willingham, M. C., Turner, J. L., Planalp, R. P., . . . Torti, S. V. (2001). p53-independent apoptosis mediated by tachpyridine, an anti-cancer iron chelator. CARCINOGENESIS, 22(10), 1607-1614. doi:10.1093/carcin/22.10.1607

Torti, S. V., Torti, F. M., Whitman, S. P., Brechbiel, M. W., Park, G., & Planalp, R. P. (1998). Tumor cell cytotoxicity of a novel metal chelator. BLOOD, 92(4), 1384-1389. doi:10.1182/blood.V92.4.1384

PLANALP, R. P., ANDERSEN, R. A., & ZALKIN, A. (1983). DIALKYL BIS[BIS(TRIMETHYLSILYL)AMIDO] GROUP-4A METAL-COMPLEXES - PREPARATION OF BRIDGING CARBENE COMPLEXES BY GAMMA-ELIMINATION OF ALKANE - CRYSTAL-STRUCTURE OF [ZRCHSI(ME)2NSIME3[N(SIME3)2])2. ORGANOMETALLICS, 2(1), 16-20. doi:10.1021/om00073a005

Most Cited Publications