Prof. Roy Planalp

Roy Planalp

ASSOCIATE PROFESSOR
Phone: (603) 862-2471
Office: Chemistry, Parsons Hall Rm W233, Durham, NH 03824
Websites:
Pronouns: He/him/his

My group studies Medicinal and Environmental Inorganic chemistry with a focus on iron, copper and zinc, both in essential and toxic senses of metal coordination and redox chemistry. We design metal ligands with conjugation to biomolecules and fluorophores in order to probe and modulate cellular metal metabolism of healthy and diseased states. Environmental analysis, sensing and nuclear medicine are also of interest. The Planalp group is currently accepting new graduate students.

Courses Taught

  • CHEM 574: Chem Across Periodic Table
  • CHEM 576: Experimental Inorganic Chem
  • CHEM 696: Independent Study
  • CHEM 774/874: Inorganic Chemistry
  • CHEM 903: Adv Inorganic Chemistry I
  • CHEM 904: Adv Inorganic Chemistry II
  • CHEM 991: Presentation Portfolio
  • CHEM 992: Graduate Writing Portfolio
  • CHEM 999: Doctoral Research
  • INCO 590: Student Research Experience
  • INCO 790: Adv Rsrch Exp/Chemistry

Education

  • Ph.D., Inorganic Chemistry, University of California - Berkeley
  • B.S., Chemistry, Massachusetts Institute of Technology

Research Interests

  • Medicinal Chemistry
  • Inorganic Chemistry
  • Synthetic Chemistry

Selected Publications

  • Nguyen, S. V., Levintov, L., Planalp, R. P., & Vashisth, H. (2024). Interactions and Transport of a Bioconjugated Peptide Targeting the Mitomembrane.. Bioconjug Chem, 35(3), 371-380. doi:10.1021/acs.bioconjchem.3c00561

  • Milam, L. R., & Planalp, R. P. (n.d.). Bimetallic Fenton-like Catalysts in the Remediation of Dyes. Colorants, 3(1), 1-16. doi:10.3390/colorants3010001

  • Chen, Y., Si, B., Cote, N., Planalp, R. P., & Seitz, R. (2023). A Telechelic Fluorescent Indicator Based on Polymer Conformational Change for Free Copper(II) Ions.. Sensors (Basel), 23(23). doi:10.3390/s23239476

  • Nyiranshuti, L., Andrews, E. R., Povolotskiy, L. I., Gomez, F. M., Bartlett, N. R., Royappa, A. T., . . . Planalp, R. P. (2023). Development of a Ratiometric Fluorescent Cu(II) Indicator Based on Poly(N-isopropylacrylamide) Thermal Phase Transition and an Aminopyridyl Cu(II) Ligand.. Molecules, 28(20). doi:10.3390/molecules28207097

  • Fulton, L. A., Seitz, W. R., & Planalp, R. P. (2020). Aggregation of poly(N-isopropylacrylamide) homopolymer by Cu2+ and Zn2+: Significance for ratiometric metal ion indicators. POLYHEDRON, 191. doi:10.1016/j.poly.2020.114797

  • Hatcher, H., Planalp, R., Cho, J., Tortia, F. M., & Torti, S. V. (2008). Curcumin: From ancient medicine to current clinical trials. CELLULAR AND MOLECULAR LIFE SCIENCES, 65(11), 1631-1652. doi:10.1007/s00018-008-7452-4

  • Jiao, Y., Wilkinson, J., Pletsch, E. C., Buss, J. L., Wang, W., Planalp, R., . . . Torti, S. V. (2006). Iron chelation in the biological activity of curcumin. FREE RADICAL BIOLOGY AND MEDICINE, 40(7), 1152-1160. doi:10.1016/j.freeradbiomed.2005.11.003

  • Abeysinghe, R. D., Greene, B. T., Haynes, R., Willingham, M. C., Turner, J. L., Planalp, R. P., . . . Torti, S. V. (2001). p53-independent apoptosis mediated by tachpyridine, an anti-cancer iron chelator. CARCINOGENESIS, 22(10), 1607-1614. doi:10.1093/carcin/22.10.1607

  • Torti, S. V., Torti, F. M., Whitman, S. P., Brechbiel, M. W., Park, G., & Planalp, R. P. (1998). Tumor cell cytotoxicity of a novel metal chelator. BLOOD, 92(4), 1384-1389. doi:10.1182/blood.V92.4.1384

  • PLANALP, R. P., ANDERSEN, R. A., & ZALKIN, A. (1983). DIALKYL BIS[BIS(TRIMETHYLSILYL)AMIDO] GROUP-4A METAL-COMPLEXES - PREPARATION OF BRIDGING CARBENE COMPLEXES BY GAMMA-ELIMINATION OF ALKANE - CRYSTAL-STRUCTURE OF [ZRCHSI(ME)2NSIME3[N(SIME3)2])2. ORGANOMETALLICS, 2(1), 16-20. doi:10.1021/om00073a005

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  • Most Cited Publications