Harish Vashisth

Harish Vashisth
ASSOCIATE PROFESSOR
Associate Professor
Chemical Engineering
Integrated Applied Mathematics
Phone: (603) 862-2483
Office: Chemical Engineering, Kingsbury Hall Rm S344B, Durham, NH 03824
Websites: Full profile: FindScholars@UNH, Vashisth Research Lab, Google Scholar
Harish Vashisth

Research Interests
Computational Biophysics, Biomolecular Simulations, Molecular Transport, Cell Signaling via Membrane Proteins

Education

  • Ph.D., Chemical Engineering, Drexel University
  • B.Tech., Chemical Engineering, National Instit of Tech

Research Interests

  • 3D Modeling / Visualization
  • Bioengineering
  • Biological Modeling
  • Biological Polymers
  • Biomedical Engineering
  • Biomimetics
  • Biomolecular Science
  • Biopharmaceuticals
  • Biophysical Interactions
  • Biophysics
  • Chemical Engineering
  • Chemical Physics
  • Computer Modeling
  • Computer Simulation/Modeling

Courses Taught

  • BENG 755: Computational Bioengineering
  • CHE 603: Appld Math for Chemical Engnrs
  • CHE 604: Chem Engnrng Thermodynamics
  • CHE 695: Chemical Engineering Project
  • CHE 923: Adv Chem Eng Thermodynamics
  • CHE 999: Doctoral Research
  • INCO 590: Rsrch Exp/Chemical Engr
  • INCO 790: Adv Rsrch Exp/Chemical Engr

Selected Publications

Levintov, L., & Vashisth, H. (2021). Role of conformational heterogeneity in ligand recognition by viral RNA molecules.. Phys Chem Chem Phys, 23(19), 11211-11223. doi:10.1039/d1cp00679g

Rocha, B. C., Paul, S., & Vashisth, H. (2021). Enhanced Porosity in Self-Assembled Morphologies Mediated by Charged Lobes on Patchy Particles.. J Phys Chem B, 125(12), 3208-3215. doi:10.1021/acs.jpcb.0c11096

Levintov, L., Paul, S., & Vashisth, H. (2021). Reaction Coordinate and Thermodynamics of Base Flipping in RNA.. J Chem Theory Comput, 17(3), 1914-1921. doi:10.1021/acs.jctc.0c01199

Liu, Y., & Vashisth, H. (2021). Allosteric Pathways Originating at Cysteine Residues in Regulators of G-Protein Signaling Proteins. BIOPHYSICAL JOURNAL, 120(3), 517-526. doi:10.1016/j.bpj.2020.12.010

Gupta, R., Liu, Y., Wang, H., Nordyke, C. T., Puterbaugh, R. Z., Cui, W., . . . Cote, R. H. (2020). Structural Analysis of the Regulatory GAF Domains of cGMP Phosphodiesterase Elucidates the Allosteric Communication Pathway. JOURNAL OF MOLECULAR BIOLOGY, 432(21), 5765-5783. doi:10.1016/j.jmb.2020.08.026

Shen, Y. -X., Song, W. C., Barden, D. R., Ren, T., Lang, C., Feroz, H., . . . Kumar, M. (2018). Achieving high permeability and enhanced selectivity for Angstrom-scale separations using artificial water channel membranes. NATURE COMMUNICATIONS, 9. doi:10.1038/s41467-018-04604-y

Vashisth, H., Skiniotis, G., & III, B. C. L. (2012). Using Enhanced Sampling and Structural Restraints to Refine Atomic Structures into Low-Resolution Electron Microscopy Maps. STRUCTURE, 20(9), 1453-1462. doi:10.1016/j.str.2012.08.007

Vashisth, H., Maragliano, L., & Abrams, C. F. (2012). "DFG-Flip" in the Insulin Receptor Kinase Is Facilitated by a Helical Intermediate State of the Activation Loop. BIOPHYSICAL JOURNAL, 102(8), 1979-1987. doi:10.1016/j.bpj.2012.03.031

Strunk, B. S., Loucks, C. R., Su, M., Vashisth, H., Cheng, S., Schilling, J., . . . Skiniotis, G. (2011). Ribosome Assembly Factors Prevent Premature Translation Initiation by 40S Assembly Intermediates. SCIENCE, 333(6048), 1449-1453. doi:10.1126/science.1208245

Vashisth, H., & Abrams, C. F. (2008). Ligand Escape Pathways and (Un)Binding Free Energy Calculations for the Hexameric Insulin-Phenol Complex. BIOPHYSICAL JOURNAL, 95(9), 4193-4204. doi:10.1529/biophysj.108.139675

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Most Cited Publications