Harish Vashisth

ASSISTANT PROFESSOR
of Chemical Engineering
Phone: (603) 862-2483
Office: Chemical Engineering, Kingsbury Hall Rm S344B, Durham, NH 03824
Harish Vashisth

Research Interests
Computational Biophysics, Biomolecular Simulations, Molecular Transport, Cell Signaling via Membrane Proteins

Education

  • Ph.D., Chemical Engineering, Drexel University
  • B.Tech., Chemical Engineering, National Instit of Tech

Courses Taught

  • BENG 755: Computational Bioengineering
  • CHE 603: Appld Math for Chemical Engnrs
  • CHE 604: Chem Engnrng Thermodynamics
  • CHE 695: Chemical Engineering Project
  • CHE 923: Adv Chem Eng Thermodynamics
  • CHE 999: Doctoral Research
  • INCO 590: Rsrch Exp/Chemical Engineering
  • INCO 790: Adv Rsrch Exp/Chemical Engr

Selected Publications

Mohammadi, M., Mohammadiarani, H., Shaw, V. S., Neubig, R. R., & Vashisth, H. (2019). Interplay of cysteine exposure and global protein dynamics in small-molecule recognition by a regulator of G-protein signaling protein. Proteins: Structure, Function, and Bioinformatics, 87(2), 146-156. doi:10.1002/prot.25642

Shen, Y. -X., Song, W., Barden, D. R., Ren, T., Lang, C., Feroz, H., . . . Kumar, M. (2018). Achieving high permeability and enhanced selectivity for Angstrom-scale separations using artificial water channel membranes. Nature Communications, 9(1). doi:10.1038/s41467-018-04604-y

Liu, Y., Mohammadi, M., & Vashisth, H. (2018). Diffusion network of CO in FeFe-Hydrogenase. The Journal of Chemical Physics, 149(20), 204108. doi:10.1063/1.5054877

Mohammadiarani, H., Shaw, V. S., Neubig, R. R., & Vashisth, H. (2018). Interpreting Hydrogen–Deuterium Exchange Events in Proteins Using Atomistic Simulations: Case Studies on Regulators of G-Protein Signaling Proteins. The Journal of Physical Chemistry B, 122(40), 9314-9323. doi:10.1021/acs.jpcb.8b07494

Shaw, V. S., Mohammadiarani, H., Vashisth, H., & Neubig, R. R. (2018). Differential Protein Dynamics of Regulators of G-Protein Signaling: Role in Specificity of Small-Molecule Inhibitors. Journal of the American Chemical Society, 140(9), 3454-3460. doi:10.1021/jacs.7b13778

Vashisth, H., & Brooks, C. L. (2012). Conformational Sampling of Maltose-Transporter Components in Cartesian Collective Variables Is Governed by the Low-Frequency Normal Modes. The Journal of Physical Chemistry Letters, 3(22), 3379-3384. doi:10.1021/jz301650q

Vashisth, H., Skiniotis, G., & Brooks, C. L. (2012). Using Enhanced Sampling and Structural Restraints to Refine Atomic Structures into Low-Resolution Electron Microscopy Maps. Structure, 20(9), 1453-1462. doi:10.1016/j.str.2012.08.007

Vashisth, H., Maragliano, L., & Abrams, C. F. (2012). “DFG-Flip” in the Insulin Receptor Kinase Is Facilitated by a Helical Intermediate State of the Activation Loop. Biophysical Journal, 102(8), 1979-1987. doi:10.1016/j.bpj.2012.03.031

Strunk, B. S., Loucks, C. R., Su, M., Vashisth, H., Cheng, S., Schilling, J., . . . Skiniotis, G. (2011). Ribosome Assembly Factors Prevent Premature Translation Initiation by 40S Assembly Intermediates. Science, 333(6048), 1449-1453. doi:10.1126/science.1208245

Vashisth, H., & Abrams, C. F. (2008). Ligand Escape Pathways and (Un)Binding Free Energy Calculations for the Hexameric Insulin-Phenol Complex. Biophysical Journal, 95(9), 4193-4204. doi:10.1529/biophysj.108.139675

Most Cited Publications